OpenIOLabs

SICM Publications

*asterisk marks papers using ionscope technology/product

2015.

*Zhou, L., Zhou, Y., Shi, W., & Baker, L. A. (2015). Alternating Current Potentiometric Scanning Ion Conductance Microscopy (AC-PSICM). J. Phys. Chem. C.

Seifert, J., Rheinlaender, J., Novak, P., Korchev, Y., & Schäffer, T. E. (2015). Comparison of atomic force microscopy and scanning ion conductance microscopy for live cell imaging. Langmuir.

*O’Connell, M. A., Lewis, J. R., & Wain, A. J. (2015). Electrochemical imaging of hydrogen peroxide generation at individual gold nanoparticles. Chem. Commun. 51:10314-10317.

Gesper, A., Thatenhorst, D., Wiese, S., Tsai, T., Dietzel, I. D., & Happel, P. (2015). Long‐term, long‐distance recording of a living migrating neuron by scanning ion conductance microscopy. Scanning37:226-231.

*Şen, M., Takahashi, Y., Matsumae, Y., Horiguchi, Y., Kumatani, A., Ino, K., & Matsue, T. (2015). Improving the Electrochemical Imaging Sensitivity of Scanning Electrochemical Microscopy-Scanning Ion Conductance Microscopy by Using Electrochemical Pt Deposition. Anal. Chem. 87: 3484-3489.

*Nashimoto, Y., Takahashi, Y., Ida, H., Matsumae, Y., Ino, K., Shiku, H., & Matsue, T. (2015). Nanoscale imaging of an unlabeled secretory protein in living cells using scanning ion conductance microscopy. Anal. Chem. 87: 2542-2545.

*Walker, S. C., Allen, S., Bell, G., & Roberts, C. J. (2015). Analysis of leaf surfaces using scanning ion conductance microscopy. J. Microsc. 258: 119-126.

 

2014.

* Zhou, Y, Bright, LK, Shi, W, Aspinwall, CA & Baker, LA (2014). Ion Channel Probes for Scanning Ion Conductance Microscopy. Langmuir 30:15351–15355.

* O’Connell, M A & Wain, AJ (2014). Mapping Electroactivity at Individual Catalytic Nanostructures Using High-Resolution Scanning Electrochemical–Scanning Ion Conductance Microcopy. Anal Chem 8612100–12107.

Takahashi, Y, Kumatani, A, Munakata, H, Inomata, H, Ito, K, Ino, K, Shiku, H, Unwin, PR, Korchev, YE, Kanamura, K & Matsue, T (2014) Nanoscale visualization of redox activity at lithium-ion battery cathodes. Nat Commun 5.

Thatenhorst, D, Rheinlaender, J, Schäffer, TE, Dietzel, ID & Happel, P (2014). Effect of Sample Slope on Image Formation in Scanning Ion Conductance Microscopy. Anal Chem 86: 9838-9845. 

Fei Z, Shi H, Zhang, Gu Y (2014). Scanning ion conductance microscopy. Optical Nanoscopy and Novel Microscopy Techniques 199-212. 

McKelvey K, Kinnear SL, Perry D, Momotenko D, Unwin, PR (2014). Surface Charge Mapping with a Nanopipette. J Am Chem Soc 136: 13735-44.

* Zhou, L, Zhou, Y, & Baker, L A (2014). Measuring Ions with Scanning Ion Conductance Microscopy. Electrochem Soc Interface, 47.

* Liu X, Li Y, Zhu H, Zhao Z, Zhou Y, Zaske, AM, Liu L, Li M, Lu H, Liu W, Dong, J.-F., Zhang, J. & Zhang, Y (2014). Use of non-contact hopping probe ion conductance microscopy to investigate dynamic morphology of live platelets. Platelets 1-6.

* Weber, AE, and Baker LA (2014). Experimental Studies of Resolution in Scanning Ion Conductance Microscopy. J Electrochem Soc 161: H924-H929.

Li P, Liu L, Wang Y, Yang Y, Zhang C, Li G. (2014). Phase modulation mode of scanning ion conductance microscopy. Appl Phys Lett 105: 053113.

Miragoli M, Yacoub MH, El-Hamamsy I, Sanchez-Alonso JL, Moshkov A, Mongkoldhumrongkul N, Padala M, Paramagurunathan S, Sarathchandra P, Korchev, YE (2014). Side Specific Mechanical Properties of Valve Endothelial Cells. Am J Physiol  Heart Circ Physiol 307: H15-H24.

Takami T, Park B, Kawai, T (2014). Nanopipette exploring nanoworld. Nano Convergence 1:1-12.

Aydemir  N, Tamm T, Travas-Sejdic J, Kilmartin PA, Aabloo A, Kiefer, R (2014). Electrochemomechanical deformation (ECMD) of PPyDBS in free standing film formation and trilayer designs. Electroact Polym Actuators Devices (EAPAD) 9056:905631-905638. 

* Zhou Y, Chen CC, Weber AE, Zhou L, Baker LA (2014). Potentiometric-Scanning Ion Conductance Microscopy. Langmuir 30: 5669-5675.

Ino K, Kanno Y, Nishijo T, Komaki H, Yamada Y, Yoshida S, Takahashi Y, Shiku H, Matsue T (2014). Densified Electrochemical Sensors Based on Local Redox Cycling between Vertically Separated Electrodes in Substrate Generation/Chip Collection and Extended Feedback Modes. Anal Chem 86:4016-4023.

* Gleisner M, Mey I, Barbot M, Dreker C, Meinecke M, Steinem C (2014). Driving a planar model system into the 3rd dimension: generation and control of curved pore-spanning membrane arrays. Soft Matter 10:6228-6236.

Yamada H (2014). Imaging a Single Living Cell via Shear Force-based Scanning Ion Conductance Microscopy in Standing Approach Mode with Differential Control. Electrochim Acta 136:233-239.

Takahashi Y, Ito K, Wang X, Matsumae Y, Komaki H, Kumatani A, Ino K, Shiku H, Matsue T (2014). Nanoscale Cell Surface Topography Imaging using Scanning Ion Conductance Microscopy. Electrochem 82: 331-334.

Iwata F, Yamazaki K, Ishizaki K, Ushiki T (2014). Local electroporation of a single cell using a scanning ion conductance microscope. Jpn J Appl Phys 53:036701.

* Zhou Y, Chen X, Liu X, Lu H, Li Y, Zhu H, An G, Zhang N, Zhang J, Ma Q, Zhang Y (2014). Phosphoinositide 3-Kinase Pathway Mediates Early Aldosterone Action on Morphology and Epithelial Sodium Channel in Mammalian Renal Epithelia. J Membr Biol 247:461-468.

* Cerrone M, Lin X, Zhang M, Agullo-Pascual E, Pfenniger A, Chkourko-Gusky H, Novelli V, Kim C, Tirasawadichai T, Judge DP, Rothenberg E, Chen HS, Napolitano C, Priori S, Delmar M (2013). Missense Mutation in Plakophilin-2 Cause Sodium Current Deficit and Associate with a Brugada Syndrome Phenotype. Circulation 129: 1092-1103.

McKelvey K, Perry D, Byers JC, Colburn AW, Unwin PR (2014). Bias modulated scanning ion conductance microscopy. Anal Chem 86: 3639-3646.

* Novak P, Shevchuk A, Ruenraroengsak P, Miragoli M, Thorley AJ, Klenerman D, Lab MJ, Tetley TD, Gorelik J, Korchev YE (2014). Imaging single nanoparticle interactions with human lung cells using fast ion conductance microscopy. Nano Lett 14: 1202-1207.

* Del Linz S, Willman E, Caldwell M, Klenerman D, Fernandez A, Moss G (2014). Contact-free scanning and imaging with the scanning ion conductance microscope. Anal Chem 86: 2353-2360.

Actis P, Tokar S, Clausmeyer J, Babakinejad B, Mikhaleva S, Cornut R, Takahashi Y, López Córdoba A, Novak P, Shevchuk AI, Dougan JA, Kazarian SG, Gorelkin PV, Erofeev AS, Yaminsky IV, Unwin PR, Schuhmann W, Klenerman D, Rusakov DA, Sviderskaya EV, Korchev YE (2014). Electrochemical nanoprobes for single-cell analysis. ACS Nano 8: 875-884.

* Wright PT, Nikolaev VO, O’Hara T, Diakonov I, Bhargava A, Tokar S, Schobesberger S, Shevchuk AI, Sikkel MB, Wilkinson R, Trayanova NA, Lyon AR, Harding SE, Gorelik J (2014). Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signalling. J Mol Cell Cardiol 67: 38-48.

Actis P, Maalouf MM, Kim HJ, Lohith A, Vilozny B, Seger RA, Pourmand N (2014). Compartmental genomics in living cells revealed by single-cell nanobiopsy. ACS Nano 8: 546-53.

 

2013.

* Zhou Y, Chen CC, Weber AE, Zhou L, Baker LA, Hou J (2013). Potentiometric-scanning ion conductance microscopy for measurement at tight junctions. Tissue Barriers 1: e25585.

* Lipson AL and Hersam M (2013). Conductive Scanning Probe Characterization and Nanopatterning of Electronic and Energy Materials. J Phys Chem C 117: 7953-7963.

* Zhang Y, Liu X, Liu L, Zaske A-M, Zhou Z, Fu Y, Yang X, Conyers JL, Li M, Dong J-f, Zhang J (2013). Contact- and agonist-regulated microvesiculation of human platelets. Thromb Haemost 110: 331-339.

* Webb K, De Filippi G, Johnston NS (2013). Condenser-free Zernike-phase contrast imaging for scanning probe microscopy. Microscopy and Analysis 7: 27-30.

Alesutan I, Seifert J, Pakladok T, Rheinlaender J, Lebedeva A, Towhid ST, Stournaras C, Voelkl J, Schäffer TE, Lang F (2013) Chorein sensitivity of actin polymerization, cell shape and mechanical stiffness of vascular endothelial cells. Cell Physiol Biochem 32: 728-742.

* Zhu H, Zhao Z, Zhou Y, Chen X, Li Y, Liu X, Lu H, Zhang Y, Zhang J (2013). High-dose glucocorticoid aggravates TBI-associated corticosteroid insufficiency by inducing hypothalamic neuronal apoptosis. Brain Res 1541: 69-80.

* Shevchuk AI, Novak P, Velazquez MA, Fleming TP, Korchev YE (2013). Combined ion conductance and fluorescence confocal microscopy for biological cell membrane transport studies. Journal of Optics 15: 094005.

* Liu X, Zhu H, Lu HJ, Li Y,  Zhang JN, Zhang YJ (2013). Real Time Investigation of Engineered Nanomaterials Cytotoxicity in Living Alveolar Epithelia with Hopping Probe Ion Conductance Microscopy. Advanced Materials Research 651: 24-28.

* Babakinejad B, Jönsson P, López Córdoba A,  Actis P, Novak P, Takahashi Y, Shevchuk A, Anand U, Anand P, Drews A, Ferrer-Montiel A, Klenerman D, Korchev YE (2013). Local Delivery of Molecules from a Nanopipette for Quantitative Receptor Mapping on Live Cells. Anal Chem 85: 9333-9342.

* Novak P, Gorelik J, Vivekananda U, Shevchuk AI, Ermolyuk YS, Bailey RJ, Bushby AJ, Moss GWJ, Rusakov DA, Klenerman D, Kullmann DM, Volynski KE, Korchev YE (2013). Nanoscale-Targeted Patch-Clamp Recordings of Functional Presynaptic Ion Channels. Neuron 79: 1067-1077.

* Thakar R, Weber AE, Morris CA, Baker LA (2013). Multifunctional carbon nanoelectrodes fabricated by focused ion beam milling. Analyst 138: 5973-5982.

Nadappuram BP, McKelvey K, Al Botros R, Colburn AW, Unwin PR (2013). Fabrication and Characterization of Dual Function Nanoscale pH-Scanning Ion Conductance Microscopy (SICM) Probes for High Resolution pH Mapping. Anal Chem 85: 8070-8074.

Lee Y, Jung GE, Cho SJ, Geckeler KE, Fuchs H (2013). Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes. Nanoscale 5: 8577-8585.

* Morris CA, Chen C-C, Ito T, Baker LA (2013). Local pH Measurements with Scanning Ion Conductance Microscopy. J Electrochem Soc 160: H430-H435.

Kim MS, Kim J, Lee W, Cho S-J, Oh J-M, Lee J-Y, Baek S, Kim YJ, Sim TS, Lee HJ, Jung G-E, Kim S-I, Park J-M, Oh JH, Gurel O, Lee SS, Lee J-G (2013). A Trachea-Inspired Bifurcated Microfilter Capturing Viable Circulating Tumor Cells via Altered Biophysical Properties as Measured by Atomic Force Microscopy. Small 9: 3103–3110.

Rheinlaender J and Schaeffer TE (2013). Mapping the mechanical stiffness of live cells with the scanning ion conductance microscope. Soft Matter 9: 3230-3236.

Mizutani Y, Choi M-H, Cho S-J, Okajima T (2013). Nanoscale fluctuations on epithelial cell surfaces investigated by scanning ion conductance microscopy. Applied Physics Letters 102: 173703-173706.

Liu BC, Song X, Lu XY, Fang C, Wei SP, Alli AA, Eaton DC, Shen BZ, Li XQ, Ma HP (2013). Lovastatin attenuates effects of cyclosporine A on tight junctions and apoptosis in cultured cortical collecting duct principal cells. Am J Physiol Renal Physiol 305: F304-F313.

Schaffer TE (2013). Nanomechanics of molecules and living cells with scanning ion conductance microscopy. Anal Chem 85: 6988-6994.

Happel P, Moller K, Schwering NK, Dietzel ID (2013). Migrating oligodendrocyte progenitor cells swell prior to soma dislocation. Sci Rep 3: 1806.

* Miragoli M, Novak P, Ruenraroengsak P, Shevchuk AI, Korchev YE, Lab MJ, Tetley TD, Gorelik J (2013). Functional interaction between charged nanoparticles and cardiac tissue: a new paradigm for cardiac arrhythmia? Nanomedicine 8: 725-737.

Parmryd I and Onfelt B (2013). Consequences of membrane topography. FEBS J 280: 2775-2784.

* Bhargava A, Gorelik J (2013). Recording single-channel currents using “smart patch-clamp” technique. Methods Mol. Biol. 998: 189-197.

* Bhargava A, Lin X, Novak P, Mehta K, Korchev Y, Delmar M, Gorelik J (2013). Super-Resolution Scanning Patch-Clamp Reveals Clustering of Ion Channels in the Adult Ventricular Myocyte. Cir Res 112: 1112-1120.

* Chen CC, Zhou Y, Morris CA, Hou J, Baker LA (2013). Scanning ion conductance microscopy measurement of paracellular channel conductance in tight junctions. Anal Chem 85: 3621-3628.

Pellegrino M, Orsini P, Pellegrini M, Tognoni E, Ascoli C, Baschieri P, Dinelli F (2013). Scanning ion conductance microscopy (SICM): from measuring cell mechanical properties to guiding neuron growth. Proc SPIE 8792 Optical Methods for Inspection, Characterisation, and Imaging of Biomaterials 87921C.

* Lorin C, Gueffier M, Bois P, Faivre J-F, Cognard C, Sebille S (2013). Ultrastructural and Functional Alterations of EC Coupling Elements in mdx Cardiomyocytes: An Analysis from Membrane Surface to Depth. Cell Biochem Biophys 66: 723-736.

* Chen X, Zhu H, Liu X, Lu H, Li Y, Wang J, Liu H, Zhang J, Ma Q, Zhang Y (2013). Characterisation of Two Mammalian Cortical Collecting Duct Cell Lines with Hopping Probe Ion Conductance Microscopy. J Membr Biol 246: 7-11.

*Klenerman D, Shevchuk A, Novak P, Korchev YE, Davis SJ (2013). Imaging the cell surface and its organization down to the level of single molecules. Philos Trans R Soc Lond B Biol Sci 368: 20120027.

Liu B-C, Lu X-Y, Song X, Lei K-Y, Alli AA, Bao H-F, Eaton DC, Ma H-P (2013). Scanning ion conductance microscopy: a nanotechnology for biological studies in live cells. Front. Physio. 3:483.

* Clarke RW, Zhukov A, Richards O, Johnson N, Ostanin V, Klenerman D (2013). Pipette – Surface interaction: current enhancement and intrinsic force. J Am Chem Soc 135: 322-329.

* Lab MJ, Bhargava A, Wright PT, Gorelik J (2013). The Scanning Ion Conductance Microscope for Cellular Physiology. Am J Physiol Heart Circ Physiol 304: H1-H11.

 

2012.

Happel P, Thatenhorst D, Dietzel ID (2012). Scanning ion conductance microscopy for studying biological samples. Sensors 12: 14983-15008.

* Caldwell M, Del Linz SJ, Smart TG, Moss GW (2012). Method for estimating the tip geometry of scanning ion conductance microscope pipets. Anal Chem 84: 8980-8984.

* Ibrahim M, Kukadia P, Siedlecka U, Cartledge JE, Navaratnarajah M, Tokar S, Van-Doorn C, Tsang VT, Gorelik J, Yacoub MH, Terracciano CM (2012). Cardiomyocyte Ca2+ Handling and Structure is Regulated by Degree and Duration of Mechanical Load Variation. J Cell Mol Med 16: 2910-2918.

Pellegrino M, Pellegrini M, Orsini P, Tognoni E, Ascoli C, Baschieri P, Dinelli F (2012). Measuring the elastic properties of living cells through the analysis of current-displacement curves in scanning ion conductance microscopy. Pflugers Arch 464: 307-316.

* Pollard A (2012). Scanning Ion Conductance Microscopy: Variable Temperature Live Cell Morphological Studies. Imaging & Microscopy 3: 42-44.

* Zhukov A, Richards O, Ostanin V, Korchev Y, Klenerman D (2012). A hybrid scanning mode for fast scanning ion conductance microscopy (SICM) imaging. Ultramicroscopy 121: 1-7.

* Takahashi Y, Shevchuk AI, Novak P, Babakinejad B, Macpherson J, Unwin PR, Shiku H, Gorelik J, Klenerman D, Korchev YE, Matsue T (2012). Topographical and electrochemical nanoscale imaging of living cells using voltage-switching mode scanning electrochemical microscopy. Proc Natl Acad Sci USA 109: 11540-11545.

* Ibrahim M, Navaratnarajah M, Siedlecka U, Rao C, Dias P, Moshkov AV, Gorelik J, Yacoub MH, Terracciano CM (2012). Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca2+-induced Ca2+release in a rodent model of heart failure. Eur J Heart Fail 14: 571-580.

Zhang S, Cho SJ, Busuttil K, Wang C, Besenbacher F, Dong M (2012). Scanning ion conductance microscopy studies of amyloid fibrils at nanoscale. Nanoscale 4: 3105-3110.

Kannan B, Williams DE, Laslau C, Travas-Sejdic J (2012). A highly sensitive, label-free gene sensor based on a single conducting polymer nanowire. Biosens Bioelectron 35: 258-64.

* Shevchuk AI, Novak P, Taylor M, Diakonov IA, Ziyadeh-Isleem A, Bitoun M, Guicheney P, Lab MJ, Gorelik J, Merrifield CJ, Klenerman D, Korchev YE (2012). An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy. J Cell Biol 97: 499-508.

* Lyon AR, Nikolaev VO, Miragoli M, Sikkel MB, Paur H, Benard L, Hulot JS, Kohlbrenner E, Hajjar RJ, Peters NS, Korchev YE, Macleod KT, Harding SE, Gorelik J (2012). Plasticity of Surface Structures and β2-Adrenergic Receptor Localization in Failing Ventricular Cardiomyocytes During Recovery From Heart Failure. Circ Heart Fail 5: 357-65.

* Chen CC, Zhou Y, Baker LA (2012). Scanning Ion Conductance Microscopy. Annu Rev Anal Chem 5:207-228.

* Zhou Y, Chen CC, Baker LA (2012). Heterogeneity of multiple-pore membranes investigated with ion conductance microscopy. Anal Chem 84: 3003-3009.

Snowden ME, Guell AG, Lai SC, McKelvey K, Ebejer N, O’Connell MA, Colburn AW, Unwin PR (2012). Scanning electrochemical cell microscopy: theory and experiment for quantitative high resolution spatially-resolved voltammetry and simultaneous ion-conductance measurements. Anal Chem 84: 2483-2491.

* Yang X, Liu X, Lu H, Zhang X, Ma L, Gao R, Zhang Y (2012). Real-time investigation of acute toxicity of ZnO nanoparticles on human lung epithelia with hopping probe ion conductance microscopy. Chem Res Toxicol 25: 297-304.

* Potter CM, Schobesberger S, Lundberg MH, Weinberg PD, Mitchell JA, Gorelik J (2012). Shape and compliance of endothelial cells after shear stress in vitro or from different aortic regions: scanning ion conductance microscopy study. PLoS One 7: e31228.

Ushiki T, Nakajima M, Choi M, Cho SJ, Iwata F (2012). Scanning ion conductance microscopy for imaging biological samples in liquid: A comparative study with atomic force microscopy and scanning electron microscopy. Micron 43: 1390-1398.

* Pollard AJ, Faruqui N, Shaw M, Clifford CA, Takahashi Y, Korchev YE, Ebejer N, Macpherson JV, Unwin PR, Roy D (2012). Development of a Novel Combined Scanning Electrochemical Microscope (SECM) and Scanning Ion Conductance Microscope (SICM) Probe for Soft Sample Imaging. MRS Proceedings 1422.

* Ruenraroengsak P, Novak P, Berhanu D, Thorley AJ, Valsami-Jones E, Gorelik J, Korchev YE, Tetley TD. (2012). Respiratory epithelial cytotoxicity and membrane damage (holes) caused by amine-modified nanoparticles. Nanotoxicology 6: 94-108.

* Morris CA, Chen CC, Baker LA (2012). Transport of redox probes through single pores measured by scanning electrochemical-scanning ion conductance microscopy (SECM-SICM). Analyst 137: 2933-2938.

 

2011.

* Lipson AL, Ginder RS, Hersam MC (2011). Nanoscale In Situ Characterisation of Li-ion Battery Electrochemistry Via Scanning Ion Conductance Microscopy. Advanced Materials 23: 5613-5617.

* Chen CC, Zhou Y, Baker LA (2011). Single nanopore investigations with ion conductance microscopy. ACS Nano 5: 8404-8411.

* Hofer I and Steinem C (2011). A membrane fusion assay based on pore-spanning lipid bilayers. Soft Matter 7: 1644-1647.

Kiilerich-Pedersen K, Poulsen CR, Jain T, Rozlosnik N (2011). Polymer based biosensor for rapid electrochemical detection of virus infection of human cells. Biosens Bioelectron 28: 386-392.

* Takahashi Y, Shevchuk AI, Novak P, Zhang Y, Ebejer N, Macpherson JV, Unwin PR, Pollard AJ, Roy D, Clifford CA, Shiku H, Matsue T, Klenerman D, Korchev YE (2011). Multifunctional Nanoprobes for Nanoscale Chemical Imaging and Localised Chemical Delivery at Surfaces and Interfaces. Angew Chem Int Ed Engl 50: 9638-9642.

* Ibrahim M, Gorelik J, Yacoub MH, Terracciano CM (2011). The structure and function of cardiac T-tubules in health and disease. Proc Biol Sci. 278: 2714-2723.

* Miragoli M, Kadir SH, Sheppard MN, Salvarani B, Virta M, Wells S, Lab MJ, Nikolaev VO, Moshkov A, Hague WM, Rohr S, Williamson C, Gorelik J (2011). A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart. Hepatology 54: 1282-1292.

* Yang X, Liu X, Zhang X, Lu H, Zhang J, Zhang Y (2011). Investigation of morphological and functional changes during neuronal differentiation of PC12 cells by combined Hopping Probe Ion Conductance Microscopy and patch-clamp technique. Ultramicroscopy 111: 1417-1422.

* Shevchuk AI, Novak P, Takahashi Y, Clarke R, Miragoli M, Babakinejad B, Gorelik J, Korchev YE, Klenerman D (2011). Realizing the biological and biomedical potential of nanoscale imaging using a pipette probe. Nanomedicine 6: 565-575.

* Klenerman D, Korchev YE, Davis SJ (2011). Imaging and characterisation of the surface of live cells. Curr. Opin. Chem. Biol. 15: 696-703.

* Liu X, Yang X, Zhang B, Zhang X, Lu H, Zhang J, Zhang Y. (2011). High resolution morphological identification and characterisation of living neuroblastoma SK-N-SH cells by hopping probe ion conductance microscopy. Brain Res. 1386: 35-40.

* Miragoli M, Moshkov A, Novak P, Shevchuk A, Nikolaev VO, El-Hamamsy I, Potter CM, Wright P, Kadir SH, Lyon AR, Mitchell JA, Chester AH, Klenerman D, Lab MJ, Korchev YE, Harding SE, Gorelik J (2011). Scanning ion conductance microscopy: a convergent high resolution technology for multi-parametric analysis of living cardiovascular cells. J. R. Soc. Interface 8: 913-925.

Laslau C, Williams DE, Wright BE, Travas-Sejdic J (2011). Measuring the ionic flux of an electrochemically actuated conducting polymer using modified scanning ion conductance microscopy. J. Am. Chem. Soc. 133: 5748-5751.

* Sun T, Donoghue PS, Higginson JR, Gadegaard N, Barnett SC, Riehle MO (2011). The interactions of astrocytes and fibroblasts with defined pore structures in static and perfusion cultures. Biomaterials 32: 2021-2031.

Pellegrino M, Orsini P, Pellegrini M, Baschieri P, Dinelli F, Petracchi D, Tognoni E, Ascoli C (2011). Weak hydrostatic forces in far-scanning ion conductance microscopy used to guide neuronal growth cones. Neurosci. Res. 69: 234-240.

* Potter CM, Lundberg MH, Harrington LS, Warboys CM, Warner TD, Berson RE, Moshkov AV, Gorelick J, Weinberg PD, Mitchell JA (2011). Role of Sheer Stress in Endothelial Cell Morphology and Expression of Cyclooxygenase Isoforms. Arterioscler. Thromb. Vasc. Biol. 31:384-391.

Elsamadisi P, Wang Y, Velmurugan J, Mirkin MV (2011). Polished Nanopipets: New Probes for High-Resolution Scanning Electrochemical Microscopy. Anal. Chem. 83: 671-673.

Rheinlaender J, Geisse NA, Proksch R, Schaffer TE (2011). Comparison of Scanning Ion Conductance Microscopy with Atomic Force Microscopy for Cell Imaging. Langmuir 27: 697-704.

*Ji T, Liang Z, Zhu X, Wang L, Liu S, Shao Y (2011). Probing the structure of a water/nitrobenzene interface by scanning ion conductance microscopy. Chem Sci 2: 1523-1529.

* Chen CC and Baker LA (2011). Effect of pipette modulation and imaging distances on ion currents measured with Scanning Ion Conductance Microscopy (SICM). Analyst 136: 90-97.

 

2010.

* Liu X, Yang X, Zhang X, Lu H, Liu L, Zhang Y (2010). [Hopping probe scanning ion conductance microscopy and its applications to topological imaging of live neuronal cells]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 27: 1365-1369, 1378 (in Chinese).

Ebejer N, Schnippering M, Colburn AW, Edwards MA, Unwin PR (2010). Localized high resolution electrochemistry and multifunctional imaging: scanning electrochemical cell microscopy. Anal. Chem. 15: 9141-9145.

* Takahashi Y, Shevchuk AI, Novak P, Murakami Y, Shiku H, Korchev YE, Matsue T (2010). Simultaneous noncontact topography and electrochemical imaging by SECM/SICM featuring ion current feedback regulation. J. Am. Chem. Soc. 132: 10118-10126.

* Takahashi Y, Murakami Y , Nagamine K, Shiku H , Aoyagi S, Yasukawa T, Kanzaki M, Matsue T (2010). Topographic imaging of convoluted surface of live cells by scanning ion conductance microscopy in a standing approach mode. Phys Chem Chem Phys 12: 10012-10017.

* Ibrahim M, Al Masri A, Navaratnarajah M, Siedlecka U, Soppa GK, Moshkov A, Al-Saud SA, Gorelik K, Yacoub MH, Terracciano CM (2010). Prolonged mechanical unloading affects cardiomyocyte excitation-contraction coupling, transverse-tubule structure, and the cell surface. FASEB J. 24: 3321-3329.

* Yang X, Liu X, Zhang XF, Lu HJ, Zhang YJ (2010). [High-resolution patch-clamp technique based on feedback control of scanning ion conductance microscopy]. Acta Physiologica Sinica 62: 275-283 (in Chinese).

Happel P, Moller K, Kunz R, Dietzel ID (2010). A boundary delimitation algorithm to approximate cell soma volumes of bipolar cells from topographical data obtained by scanning probe microscopy. BMC Bioinformatics 11: 323.

* Comstock DJ, Elam JW, Pellin MJ, Hersam MC (2010). Integrated ultramicroelectrode-nanopipet probe for concurrent scanning electrochemical microscopy and scanning ion conductance microscopy. Anal. Chem. 82: 1270-1276.

* Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ, Korchev YE, Harding SE, Gorelik J (2010). Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science 327: 1653-1657.

* James AF, Sabirov RZ, Okada Y (2010). Clustering of protein kinase A-dependent CFTR chloride channels in the sarcolemma of guinea-pig ventricular myocytes. Biochem. Biophys. Res. Commun. 391: 841-845.

* Adler J, Shevchuk AI, Novak P, Korchev YE, Parmryd I (2010). Plasma membrane topography and interpretation of single-particle tracks. Nat. Methods 7: 170-171.

 

2009.

Happel P and Dietzel ID (2009). Backstep scanning ion conductance microscopy as a tool for long term investigation of single living cells. J. Nanobiotechnology 7: 7.

Rheinlander J and Schaffer TE (2009). Image formation, resolution, and height measurement in scanning ion conductance microscopy. Journal of Applied Physics 105: 094905.

Pellegrino M. Orsini P, De Gregorio F (2009). Use of scanning ion conductance microscopy to guide and redirect neuronal growth cones. Neurosci. Res. 64: 290-296.

* Chen C, Derylo MA, Baker LA (2009). Measurement of ion currents through porous membranes with scanning ion conductance microscopy. Anal. Chem. 81: 4742-4751.

Edwards M, Williams C, Whitworth AL, Unwin PR (2009). Scanning ion conductance microscopy: a model for experimentally realistic conditions and image interpretation. Anal. Chem. 81: 4482-4492.

* Novak P, Li C, Shevchuk AI, Stepanyan R, Caldwell M, Hughes S, Smart TG, Gorelik J, Ostanin VP, Lab MJ, Moss GW, Frolenkov GI, Klenerman D, Korchev YE (2009). Nanoscale live-cell imaging using hopping probe ion conductance microscopy. Nat. Methods 6: 279-281.

Bocker M, Muschter S, Schmitt EK, Steinem C, Schaffer TE (2009). Imaging and patterning of pore-suspending membranes with scanning ion conductance microscopy. Langmuir 25: 3022-3028.

* Lyon AR, MacLeod KT, Zhang Y, Garcia E, Kanda GK, Lab MJ, Korchev YE, Harding SE, Gorelik J (2009). Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc. Natl. Acad. Sci. USA 106: 6854-6859.

* Lin L (2009). Applications of nanopipettes in bionanotechnology. Biochem. Soc. Trans. 37: 702-706.

 

2008.

* Gorelik J, Ali NN, Sheikh Abdul Kadir SH, Lab M, Stojkovic P, Armstrong L, Sviderskaya EV, Negulyaev YA, Klenerman D, Bennett DC, Lako M, Harding SE, Stojkovic M, Korchev YE (2008). Non-invasive imaging of stem cells by scanning ion conductance microscopy: future perspective. Tissue Eng. Part C Methods 14: 311-318.

* Kemp SJ, Thorley AJ, Gorelik J, Seckl MJ, O’Hare MJ, Arcaro A, Korchev Y, Goldstraw P, Tetley TD (2008). Immortalization of human alveolar epithelial cells to investigate nanoparticle uptake. Am. J. Respir. Cell. Mol. Biol. 39: 591-597.

Mann SA, Versmold B, Marx R, Stahlhofen S, Dietzel ID, Heumann R, Berger R (2008). Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats. J. Neuroinflammation 5: 39.

* Sanchez D, Johnson N, Li C, Novak P, Rheinlaender J, Zhang Y, Anand U, Anand P, Gorelik J, Frolenkov GI, Benham C, Lab M, Ostanin VP, Schaffer TE, Klenerman D, Korchev YE (2008). Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette. Biophys. J. 95: 3017-3027.

* Piper JD, Li C, Lo CJ, Berry R, Korchev Y, Ying L, Klenerman D (2008). Characterisation and application of controllable local chemical changes produced by reagent delivery from a nanopipette. J. Am. Chem. Soc. 130: 10386-10393.

* Shevchuk AI, Hobson P, Lab MJ, Klenerman D, Krauzewicz N, Korchev YE (2008). Imaging single virus particles on the surface of cell membranes by high-resolution scanning surface confocal microscopy. Biophys. J. 94: 4089-4094.

* Shevchuk AI, Hobson P, Lab MJ, Klenerman D, Krauzewicz N, Korchev YE (2008). Endocytic pathways: combined scanning ion conductance and surface confocal microscopy study. Pflugers Archiv. 456: 227-235.

* Dutta AK, Korchev YE, Shevchuk AI, Hayashi S, Okada Y, Sabirov RZ (2008). Spatial distribution of maxi-anion channel on cardiomyocytes detected by smart-patch technique. Biophys. J. 94: 1646-1655.

 

2007.

Bocker M, Anczykowski B, Wegener J, Schaffer TE (2007). Scanning ion conductance microscopy with distance-modulated shear force control. Nanotechnology 18: 145505.

* Bruckbauer A, James P, Zhou D, Yoon JW, Excell D, Korchev Y, Jones R, Klenerman D (2007). Nanopipette delivery of individual molecules to cellular compartments for single-molecule fluorescence tracking. Biophys. J. 93: 3120-3131.

* Zhang Y, Sanchez D, Gorelik J, Klenerman D, Lab M, Edwards C, Korchev Y (2007). Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia. Am. J. Physiol. Renal Physiol. 292: F1734-F1740.

* Sanchez D, Anand U, Gorelik J, Benham CD, Bountra C, Lab M, Klenerman D, Birch R, Anand P, Korchev Y (2007). Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy. J. Neurosci. Methods 159: 26-34.

 

2006.

* Piper JD, Clarke RW, Korchev YE, Ying L, Klenerman D (2006). A renewable nanosensor based on a glass nanopipette. J. Am. Chem. Soc. 128: 16462-16463.

* Gorelik J, Yang LQ, Zhang Y, Lab M, Korchev Y, Harding SE (2006). A novel Z groove index characterising myocardial surface structure. Cardiovasc. Res. 72: 422-429.

Mann SA, Meyer JW, Dietzel ID (2006). Integration of a scanning ion conductance microscope into phase contrast optics and its application to the quantification of morphological parameters of selected cells. J. Microsc. 224: 152-157.

Shin W and Gillis KD (2006). Measurement of changes in membrane surface morphology associated with exocytosis using scanning ion conductance microscopy. Biophys J. 91: L63-65.

* Klenerman D and Korchev YE (2006). Potential biomedical applications of the scanned nanopipette. Nanomedicine 1: 107-114.

* Gorelik J, Ali NN, Shevchuk AI, Lab M, Williamson C, Harding SE, Korchev YE (2006). Functional characterization of embryonic stem cell-derived cardiomyocytes using scanning ion conductance microscopy. Tissue Eng. 12: 657-664.

* Shevchuk AI, Frolenkov GI, Sanchez D, James PS, Freedman N, Lab MJ, Jones R, Klenerman D, Korchev YE (2006). Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy. Angew Chem. Int. Ed. Engl. 45: 2212-2216.

* Rodolfa KT, Bruckbauer A, Zhou D, Shevchuk AI, Korchev YE, Klenerman D (2006). Nanoscale pipetting for controlled chemistry in small arrayed water droplets using a double-barrel pipet. Nano Lett. 6: 252-257.

 

2005.

* Gorelik J, Zhang Y, Sanchez D, Shevchuk A, Frolenkov G, Lab M, Klenerman D, Edwards C, Korchev Y (2005). Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited. PNAS 102: 15000-15005.

* Rodolfa KT, Bruckbauer A, Zhou D, Korchev YE, Klenerman D (2005). Two-component graded deposition of biomolecules with a double-barreled nanopipette. Angew Chem. Int. Ed. Engl. 44: 6854-59.

* Zhang Y, Gorelik J, Sanchez D, Shevchuk A, Lab M, Vodyanoy I, Klenerman D, Edwards C, Korchev Y (2005). Scanning ion conductance microscopy reveals how a functional renal epithelial monolayer maintains its integrity. Kidney Int. 68: 1071-1077.

* Duclohier H (2005). Neuronal sodium channels in ventricular heart cells are localized near T-tubules openings. Biochem. Biophys. Res. Commun. 334: 1135-40.

* Ying L, Bruckbauer A, Zhou D, Gorelik J, Shevchuk A, Lab M, Korchev Y, Klenerman D (2005). The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules. Phys. Chem. Chem. Phys. 7: 2859-66.

* Clarke RW, White SS, Zhou D, Ying L, Klenerman D (2005). Trapping of proteins under physiological conditions in a nanopipette. Angew Chem. Int. Ed. Engl. 44: 3747-50.

Adenle O and Fitzgerald W (2005). Simulating imaging with the scanning ion-conductance microscope. Conf. Proc. IEEE Eng. Med. Biol. Soc. 4: 3410-3413.

 

2004.

* Gorelik J, Shevchuk A, de Swiet M. Lab M, Korchev Y, Williamson C (2004). Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes. BJOG 111: 867-870.

* Bruckbauer A, Zhou D, Kang DJ, Korchev YE, Abell C, Klenerman D (2004). An addressable antibody nanoarray produced on a nanostructured surface. J. Am. Chem. Soc. 126: 6508-6509.

* Gorelik J, Zhang Y, Shevchuk AI, Frolenkov GI, Sanchez D, Lab MJ, Vodyanoy I, Edwards CR, Klenerman D, Korchev YE (2004). The use of scanning ion conductance microscopy to image A6 cells. Mol. Cell. Endocrinol. 217: 101-118.

* Ying L, White SS, Bruckbauer A, Meadows L, Korchev YE, Klenerman D (2004). Frequency and voltage dependence of the dielectrophoretic trapping of short lengths of DNA and dCTP in a nanopipette. Biophys. J. 86: 1018-1027.

* Darszon A, Wood CD, Beltran C, Sanchez D. Rodriguez E, Gorelik J, Korchev YE, Nishigaki T (2004). Measuring ion fluxes in sperm. Methods Cell. Biol. 74: 545-576.

 

2003.

Happel P, Hoffmann G, Mann SA, Dietzel ID (2003). Monitoring cell movements and volume changes with pulse-mode scanning ion conductance microscopy. J. Microsc. 212: 144-151.

* Gorelik J, Vodyanoy I, Shevchuk AI, Diakonov IA, lab MJ, Korchev YE (2003). Esmolol is antiarrhythmic in doxorubicin-induced arrhythmia in cultured cardiomyocytes – determination by novel rapid cardiomyocyte assay. FEBS Lett. 548: 74-78.

* Bruckbauer A, Zhou D, Ying L, Korchev YE, Abell C, Klenerman D (2003). Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet. J. Am. Chem. Soc. 125: 9834-9839.

* Gorelik J, Shevchuk AI, Frolenkov GI, Diakonov IA, Lab MJ, Kros CJ, Richardson GP, Vodyanoy I, Edwards CR, Klenerman D, Korchev YE (2003). Dynamic assembly of surface structures in living cells. PNAS 100: 5819-5822.

* Gorelik J, Shevchuk AI, Diakonov I, de Swiet M, Lab M, Korchev Y, Williamson C (2003). Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes. BJOG 110: 467-474.

* Rothery AM, Gorelik J, Bruckbauer A, Yu W, Korchev YE, Klenerman D (2003). A novel light source for SICM-SNOM of living cells. J. Microsc. 209: 94-101.

 

2002.

* Gorelik J, Gu Y, Spohr HA, Shevchuk AI, Lab MJ, Harding SE, Edwards CR, Whitaker M, Moss GW, Benton DC, Sanchez D, Darszon A, Vodyanoy I, Klenerman D, Korchev YE (2002). Ion channels in small cells and subcellular structures can be studied with a smart patch-clamp system. Biophys. J. 83: 3296-3303.

* Gorelik J, Shevchuk A, Ramalho M, Elliott M, Lei C, Higgins CF, Lab MJ, Klenerman D, Krauzewicz N, Korchev Y (2002). Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: application to single virus-like particle entry into a cell. PNAS 99: 16018-160123.

* Siwy Z, Gu Y, Spohr HA, Baur D, Wolf-Reber A, Spohr R, Apel P, Korchev YE (2002). Rectification and voltage gating of ion currents in a nanofabricated pore. Europhys. Lett. 60: 349-355.

* Gorelik J, Harding SE, Shevchuk AI, Koralage D, Lab M, de Swiet M, Korchev Y, Williamson C (2002). Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics. Clin Sci. 103: 191-200.

* Bruckbauer A, Ying L, Rothery AM, Zhou D, Shevchuk AI, Abell C, Korchev YE, Klenerman D (2002). Writing with DNA and protein using a nanopipette for controlled delivery. J. Am. Chem. Soc. 124: 8810-8811.

* Bruckbauer A, Ying L, Rothery AM, Korchev YE, Klenerman D (2002). Characterisation of a novel light source for simultaneous optical and scanning ion conductance microscopy. Anal. Chem. 74: 2612-2616.

Mann SA, Hoffmann G, Hengstenberg A, Schuhmann W, Dietzel ID (2002). Pulse-mode scanning ion conductance microscopy – a method to investigate cultured hippocampal cells. J. Neurosci. Methods 116: 113-117.

* Gu Y, Gorelik J, Spohr HA, Shevchuk A, Lab MJ, Harding SE, Vodyanoy I, Klenerman D, Korchev YE (2002). High resolution scanning patch-clamp: new insights into cell function. FASEB J. 16: 748-750.

* Ying L, Bruckbauer A, Rothery AM, Korchev YE, Klenerman D (2002). Programmable delivery of DNA through a nanopipette. Anal Chem. 74: 1380-1385.

Mannelquist A, Iwamoto H, Szabo G, Shao Z (2002). Near field optical microscopy in aqueous solution: implementation and characterisation of a vibrating probe. J. Microsc. 205: 53-60.

 

2001.

Pastre’ D, Iwamoto H, Liu J, Szabo G, Shao Z (2001). Characterisation of AC mode scanning ion-conductance microscopy. Ultramicroscopy 90: 13-19.

* Shevchuk AI, Gorelik J, Harding SE, Lab MJ, Klenerman D, Korchev YE (2001). Simultaneous measurement of Ca2+ and cellular dynamics: combined scanning ion conductance and optical microscopy to study contracting cardiac myocytes. Biophys. J. 81: 1759-1764.

* Williamson C, Gorelik J, Eaton BM, Lab M, de Swiet M, Korchev YE (2001). The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis. Clin. Sci. 100: 363-369.

 

2000.

* Korchev YE, Negulyaev YA, Edwards CR, Vodyanoy I, Lab MJ (2000). Functional localisation of single active ion channels on the surface of a living cell. Nat. Cell. Biol. 2: 616-619.

* Korchev YE, Raval M, Lab MJ, Gorelik J, Edwards CR, Rayment T, Klenerman D (2000). Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells. Biophys. J. 78: 2675-2679.

* Korchev YE, Gorelik J, Lab MJ, Sviderskaya EV, Johnston CL, Coombes CR, Vodyanoy I, Edwards CR (2000). Cell volume measurement using scanning ion conductance microscopy. Biophys. J. 78: 451-457.

 

1999.

Zhang, H, Wu, L & Huang, F (1999). Electrochemical microprocess by scanning ion-conductance microscopy. J. Vac. Sci. Technol. B  17: 269-272.

 

1998.

Nitz H, Kamp J, Fuchs H (1998). A Combined Scanning Ion-Conductance and Shear-Force Microscope. Probe Microscopy 1: 187-200.

 

1997.

* Korchev YE, Milovanovic M, Bashford CL, Bennett DC, Sviderskaya EV, Vodyanoy I, Lab MJ (1997). Specialized scanning ion-conductance microscope for imaging of living cells. J. Microsc. 188: 17-23.

* Korchev YE, Bashford CL, Milovanovic M, Vodyanoy I, Lab MJ (1997). Scanning ion conductance microscopy of living cells. Biophys. J. 73: 653-658.

 

1996.

Proksch R, Lal R, Hansma PK, Morse D, Stucky G (1996). Imaging the internal and external pore structure of membranes in fluid: TappingMode scanning ion conductance microscopy. Biophys. J. 71: 2155-2157.

 

1990.

Prater, CB, Hansma, PK, Tortonese, M and Quate, CF (1991).  Improved scanning ion-conductance microscope using microfabricated probes. Rev. Sci. Instrum. 62: 2634-2638.

 

1989.

Hansma PK, Drake B, Marti O, Gould SA, Prater CB (1989). The scanning ion-conductance microscope. Science 243: 641-643.